Standard Name	SUR4 (see Nomenclature conflict Note)
Systematic Name	YLR372W
Alias	ELO3 , SRE1 , VBM1 , APA1
Feature Type	ORF, Verified
Description	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis (1, 2)
Name Description	SUppressor of Rvs161 and rvs167 mutations 3

Chromosomal Location	ChrXII:867354 to 868391 | ORF Map | GBrowse

	View Computational GO annotations for SUR4
Molecular Function
Manually curated	fatty acid elongase activity (IMP)
Biological Process
Manually curated	fatty acid biosynthetic process (IMP) fatty acid elongation (IMP) post-Golgi vesicle-mediated transport (IGI) sphingolipid biosynthetic process (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA)
High-throughput	integral to membrane (ISM)

Pathways	very long chain fatty acid biosynthesis

Classical genetics
null	budding pattern: abnormal lithium(1+) accumulation: decreased mannosylinositol phosphorylceramide accumulation: decreased ceramide accumulation: increased prion formation: decreased Kre2p-myc accumulation: decreased Kre2p-GFP distribution: abnormal Fus-Mid-GFP distribution: abnormal Ptr2p-GFP distribution: abnormal replicative lifespan: decreased resistance to FK506: decreased toxin resistance: decreased viable
overexpression	resistance to edelfosine: decreased
unspecified	resistance to hygromycin B: increased
Large-scale survey
null	budding pattern: abnormal cell shape: abnormal competitive fitness: decreased fermentative growth: decreased rate haploproficient heat sensitivity: increased ionic stress resistance: decreased metal resistance: increased nutrient utilization: decreased Can1p-GFP distribution: abnormal Fus-Mid-GFP distribution: abnormal resistance to ethanol: decreased resistance to hydroxyurea: decreased resistance to monensin: decreased resistance to methyl methanesulfonate: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to camptothecin: increased resistance to calcium dichloride: decreased resistance to caffeine: decreased resistance to glycolaldehyde: decreased resistance to St. John's Wort extract: decreased resistance to FK506: decreased resistance to sulfometuron methyl: decreased resistance to acetic acid: decreased resistance to sodium arsenite: decreased resistance to quinine: decreased resistance to pentachlorophenol: decreased resistance to sirolimus: decreased resistance to dimethyl sulfoxide: decreased resistance to edelfosine: decreased resistance to mefloquine: decreased resistance to benzo[a]pyrene: decreased resistance to L-canavanine: increased telomere length: decreased toxin resistance: increased transposable element transposition: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	558 total interaction(s) for 380 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 PCA: 81
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 153 Phenotypic Enhancement: 7 Phenotypic Suppression: 81 Positive Genetic: 157 Synthetic Growth Defect: 14 Synthetic Lethality: 9 Synthetic Rescue: 44
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:867354 to 868391 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1038 867354..868391 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004364