SFH1/YLR321C Summary Help

Standard Name SFH1
Systematic Name YLR321C
Feature Type ORF, Verified
Description Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog (1, 2, 3, 4, 5)
Name Description Snf Five Homolog
Chromosomal Location
ChrXII:777864 to 776584 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SFH1 GO evidence and references
  View Computational GO annotations for SFH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
repressible
Large-scale survey
null
reduction of function
Resources
130 total interaction(s) for 54 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 84
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Co-purification: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 15
  • Phenotypic Enhancement: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 426
Molecular Weight (Da) 48,777
Isoelectric Point (pI) 4.91
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:777864 to 776584 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1281 777864..776584 2004-02-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004313
References cited on this page View Complete Literature Guide for SFH1
1) Cao Y, et al.  (1997) Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression. Mol Cell Biol 17(6):3323-34
2) Cairns BR, et al.  (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60
3) Lorch Y, et al.  (1999) Histone octamer transfer by a chromatin-remodeling complex. Cell 96(3):389-92
4) Hsu JM, et al.  (2003) The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol Cell Biol 23(9):3202-15
5) Campsteijn C, et al.  (2007) Reverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenance. PLoS Genet 3(6):e92