MMS22/YLR320W Summary Help

Standard Name MMS22 1
Systematic Name YLR320W
Alias SLM2 2
Feature Type ORF, Verified
Description Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation (1, 2, 3, 4, 5)
Name Description Methyl MethaneSulfonate sensitivity 1
Chromosomal Location
ChrXII:771940 to 776304 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MMS22 GO evidence and references
  View Computational GO annotations for MMS22
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
overexpression
repressible
Large-scale survey
null
Resources
472 total interaction(s) for 305 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-Western: 9
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 215
  • Positive Genetic: 41
  • Synthetic Growth Defect: 136
  • Synthetic Lethality: 42
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,454
Molecular Weight (Da) 167,681
Isoelectric Point (pI) 6.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:771940 to 776304 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4365 771940..776304 2004-02-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004312
References cited on this page View Complete Literature Guide for MMS22
1) Bennett CB, et al.  (2001) Genes required for ionizing radiation resistance in yeast. Nat Genet 29(4):426-34
2) Araki Y, et al.  (2003) Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability. Genes Cells 8(5):465-80
3) Jordan PW, et al.  (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222
4) Duro E, et al.  (2008) Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage. DNA Repair (Amst) 7(5):811-8
5) Vaisica JA, et al.  (2011) Mms1 and Mms22 stabilize the replisome during replication stress. Mol Biol Cell 22(13):2396-408