SDC1/YDR469W Summary Help

Standard Name SDC1 1
Systematic Name YDR469W
Alias CPS25 2 , SAF19 3
Feature Type ORF, Verified
Description Subunit of the COMPASS (Set1C) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 (2, 4, 5, 6, 7, 8)
Name Description Set1c, homologue of Dpy30 from C.elegans
Chromosomal Location
ChrIV:1399015 to 1399542 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SDC1 GO evidence and references
  View Computational GO annotations for SDC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
356 total interaction(s) for 206 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 41
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 4
  • Co-crystal Structure: 1
  • Co-purification: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 7

Genetic Interactions
  • Negative Genetic: 221
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 1
  • Positive Genetic: 17
  • Synthetic Growth Defect: 28
  • Synthetic Lethality: 21
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 175
Molecular Weight (Da) 19,446
Isoelectric Point (pI) 4.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1399015 to 1399542 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..528 1399015..1399542 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002877
References cited on this page View Complete Literature Guide for SDC1
1) Samanta MP and Liang S  (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
2) Miller T, et al.  (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
3) Nagy PL, et al.  (2002) A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A 99(1):90-4
4) Roguev A, et al.  (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24):7137-48
5) Krogan NJ, et al.  (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
6) Sun ZW and Allis CD  (2002) Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418(6893):104-8
7) Dover J, et al.  (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
8) South PF, et al.  (2010) A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression. J Biol Chem 285(1):595-607