Standard Name	PAP1 1 (see Nomenclature conflict Note)
Systematic Name	YKR002W
Feature Type	ORF, Verified
Description	Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping (2, 3, 4, 5, 6)
Name Description	Poly(A) Polymerase 1

Chromosomal Location	ChrXI:443232 to 444938 | ORF Map | GBrowse
	Genetic position: -1 cM

	View Computational GO annotations for PAP1
Molecular Function
Manually curated	polynucleotide adenylyltransferase activity (IDA)
Biological Process
Manually curated	mRNA polyadenylation (IDA, IMP) snoRNA polyadenylation (IGI)
Cellular Component
Manually curated	mRNA cleavage and polyadenylation specificity factor complex (IDA) nucleoplasm (IPI)

Classical genetics
conditional	mRNA accumulation: decreased HHF2 mRNA accumulation: decreased poly(A)+ RNA accumulation: decreased TRF4 mRNA accumulation: decreased 3' extended forms of NAB2 mRNA accumulation: increased SSA4 mRNA localization: abnormal rRNA modification: decreased heat sensitivity: increased vegetative growth: decreased
Large-scale survey
null	haploinsufficient inviable
overexpression	cell cycle progression: abnormal inviable vegetative growth: decreased rate
reduction of function	competitive fitness: increased
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	153 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 99 Affinity Capture-Western: 16 Biochemical Activity: 2 Co-crystal Structure: 1 Co-localization: 1 Co-purification: 1 Reconstituted Complex: 8 Two-hybrid: 9
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 2 Synthetic Growth Defect: 3 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:443232 to 444938 | ORF Map | GBrowse
	Genetic position: -1 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1707 443232..444938 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001710