PXA2/YKL188C Summary Help

Standard Name PXA2 1 (see Nomenclature conflict Note)
Systematic Name YKL188C
Alias PAT1
Feature Type ORF, Verified
Description Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder (1, 2, 3, 4)
Name Description PeroXisomal ABC-transporter 1
Chromosomal Location
ChrXI:88786 to 86225 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PXA2 GO evidence and references
  View Computational GO annotations for PXA2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant phenotypes All PXA2 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
Resources
interactions All PXA2 Interaction evidence and references
31 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • PCA: 1
  • Two-hybrid: 1
Genetic Interactions
  • Negative Genetic: 20
  • Phenotypic Enhancement: 1
  • Positive Genetic: 5
  • Synthetic Lethality: 1
Resources
Expression Summary
histogram
Resources
Protein Information All PXA2 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:88786 to 86225 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2562 88786..86225 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000001671

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
GNA1Nomenclature conflictPAT1 has been used in the literature to refer to both PXA2/YKL188C, which encodes a ABC transporter-2, and GNA1/YFL017C, which encodes a glucosamine-phosphate N-acetyltransferase.
PAT1Nomenclature conflictPAT1 has been used in the literature to refer to both PAT1/YCR077C, which is involved in translational initiation and chromosome segregation, and PXA2/YKL188C, which encodes a ABC transporter-2.
References cited on this page View Complete Literature Guide for PXA2
1) Shani N and Valle D  (1996) A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters. Proc Natl Acad Sci U S A 93(21):11901-6
2) Verleur N, et al.  (1997) Transport of activated fatty acids by the peroxisomal ATP-binding-cassette transporter Pxa2 in a semi-intact yeast cell system. Eur J Biochem 249(3):657-61
3) Shani N, et al.  (1996) An S. cerevisiae peroxisomal transporter, orthologous to the human adrenoleukodystrophy protein, appears to be a heterodimer of two half ABC transporters: Pxa1p and Pxa2p. Ann N Y Acad Sci 804:770-2
4) Hettema EH, et al.  (1996) The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. EMBO J 15(15):3813-22