APE2/YKL157W Summary 
| Standard Name | APE2 |
|---|---|
| Systematic Name | YKL157W |
| Alias | LAP1 , YKL158W |
| Feature Type | ORF, Verified |
| Description | Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication (1, 2, 3, 4 and see Summary Paragraph) |
| Name Description | AminoPEptidase |
| Chromosomal Location | |
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| Genetic position: -124.8 cM |
Gene Ontology Annotations All APE2 GO evidence and references
| View Computational GO annotations for APE2 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All APE2 Phenotype evidence and references
| Large-scale survey | |
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| null |
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| overexpression | |
| Resources |
interactions All APE2 Interaction evidence and references
| 84 total interaction(s) for 70 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All APE2 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| This feature contains embedded feature(s): YKL158W | |||||||||||||||||||||||
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| Genetic position: -124.8 cM | |||||||||||||||||||||||
| Last Update | Coordinates: 2011-02-03 | Sequence: 2011-02-03 | ||||||||||||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||||||||||||
Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000001640 |
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SUMMARY PARAGRAPH for APE2
APE2 encodes one of four leucine aminopeptidases in yeast (5). It has sequence similarity to members of the zinc-dependent metallopeptidase gene family (3). Ape2p seems to be involved in peptide metabolism, in the cellular supply of leucine from externally offered leucine-containing dipeptide substrates (2, 5). Ape2p has also been referred to as Lap1p, and aminopeptidase yscII (3). Ape2p is distributed in the periplasmic space and cytoplasm (3).
Last updated: 1999-09-01 
References cited on this page View Complete Literature Guide for APE2
| 1) | Davis CA, et al. (2000) Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast. Nucleic Acids Res 28(8):1700-6 |
| 2) | Hirsch HH, et al. (1988) Aminopeptidase yscII of yeast. Isolation of mutants and their biochemical and genetic analysis. Eur J Biochem 173(3):589-98 |
| 3) | Garcia-Alvarez N, et al. (1991) Molecular cloning of soluble aminopeptidases from Saccharomyces cerevisiae. Sequence analysis of aminopeptidase yscII, a putative zinc-metallopeptidase. Eur J Biochem 202(3):993-1002 |
| 4) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 5) | Trumbly RJ and Bradley G (1983) Isolation and characterization of aminopeptidase mutants of Saccharomyces cerevisiae. J Bacteriol 156(1):36-48 |
