SUMMARY PARAGRAPH for IMP2'
IMP2' was originally isolated as a mutant defective in maltose, galactose and raffinose metabolism (2). IMP2' is required for the rapid glucose derepression of the maltose, galactose, raffinose and ethanol utilization pathways, and it has been shown that Imp2'p regulates galactose- and maltose-inducible genes at the transcriptional level (5). In addition, molecular analysis of IMP2' indicates that it encodes a transcription factor that can activate a reporter gene (4). IMP2' was also isolated in a screen for bleomycin mutants; bleomycin is an antitumor drug that damages DNA by producing free radicals (4). imp2' mutants are sensitive to other DNA damaging agents, suggesting that Imp2p' is involved in regulation of genes involved in DNA repair (4).
Note: this gene is designated IMP2' in SGD because another gene has also been referred to as IMP2 in the literature. The other IMP2 gene (ORF YMR035W) is a mitochondrial protease that cleaves signal sequences from proteins targeted to the mitochondrial intermembrane space.
Last updated: 2000-06-09