Standard Name	BEM2 1, 2 (see Nomenclature conflict Note)
Systematic Name	YER155C
Alias	IPL2 3 , SUP9 , TSL1
Feature Type	ORF, Verified
Description	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence (4, 5)
Name Description	Bud EMergence 2

Chromosomal Location	ChrV:482848 to 476345 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 119 cM

	View Computational GO annotations for BEM2
Molecular Function
Manually curated	Rho GTPase activator activity (IDA)
Biological Process
Manually curated	actin cytoskeleton organization (IGI, TAS) establishment of cell polarity (TAS) fungal-type cell wall organization (TAS) negative regulation of Rho protein signal transduction (IGI, IMP)
Cellular Component
Manually curated	cell cortex (IDA) cellular bud tip (IDA) cytoplasm (IDA) incipient cellular bud site (IDA) mating projection tip (IDA) plasma membrane (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	actin cytoskeleton morphology: abnormal budding: delayed Gic2p accumulation: decreased Cdc42p-GTP accumulation: increased Cdc24p-GFP distribution: abnormal Cdc24p modification: increased resistance to ethanol: decreased resistance to Calcofluor White: decreased resistance to benomyl: decreased resistance to enzymatic treatment: decreased vegetative growth: decreased
overexpression	vegetative growth: decreased
unspecified	sterol accumulation: decreased
Large-scale survey
null	cell size: increased competitive fitness: decreased endocytosis: decreased fermentative growth: decreased rate heat sensitivity: increased lipid particle morphology: abnormal resistance to quinine: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to hydrogen chloride: decreased resistance to acetic acid: decreased resistance to Echinacea extract: decreased resistance to fluconazole: decreased resistance to caffeine: decreased resistance to benomyl: decreased resistance to arsenite(3-): decreased resistance to ethanol: decreased resistance to hydroxyurea: decreased resistance to sorbic acid: decreased resistance to wortmannin: decreased resistance to sirolimus: decreased resistance to sirolimus: increased resistance to cycloheximide: increased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to methyl methanesulfonate: decreased resistance to mycophenolic acid: decreased resistance to elesclomol-Cu: decreased resistance to glycolaldehyde: decreased respiratory growth: absent sporulation efficiency: increased transposable element transposition: increased utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	443 total interaction(s) for 291 unique genes/features.
Physical Interactions	Affinity Capture-MS: 56 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 2 Co-fractionation: 2 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 241 Phenotypic Enhancement: 6 Phenotypic Suppression: 2 Positive Genetic: 32 Synthetic Growth Defect: 24 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 58 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:482848 to 476345 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 119 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..6504 482848..476345 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000957