Standard Name	SYP1 1
Systematic Name	YCR030C
Alias	YCR029C-A
Feature Type	ORF, Verified
Description	Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization (1, 2, 3)
Name Description	Suppressor of Yeast Profilin deletion 1

Chromosomal Location	ChrIII:176438 to 173826 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SYP1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	actin cortical patch assembly (IMP) septin cytoskeleton organization (IGI, IMP, IPI)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) mating projection base (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
null	endocytosis: decreased Ede1p-GFP distribution: abnormal
overexpression	cellular morphology: abnormal
Large-scale survey
null	competitive fitness: increased endocytosis: decreased resistance to dimethyl sulfoxide: decreased sporulation: normal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	81 total interaction(s) for 58 unique genes/features.
Physical Interactions	Affinity Capture-MS: 24 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Biochemical Activity: 1 Co-crystal Structure: 1 Co-localization: 1 PCA: 21 Reconstituted Complex: 2 Two-hybrid: 6
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 5 Negative Genetic: 9 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:176438 to 173826 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2000-09-13
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2613 176438..173826 2011-02-03 2000-09-13
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000626