ZRT2/YLR130C Summary Help

Standard Name ZRT2 1
Systematic Name YLR130C
Feature Type ORF, Verified
Description Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor (1, 2 and see Summary Paragraph)
Name Description Zinc-Regulated Transporter 1
Chromosomal Location
ChrXII:404062 to 402794 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ZRT2 GO evidence and references
  View Computational GO annotations for ZRT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
19 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 3
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 9
  • Phenotypic Enhancement: 3
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 422
Molecular Weight (Da) 46,363
Isoelectric Point (pI) 4.93
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:404062 to 402794 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1269 404062..402794 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000004120
SUMMARY PARAGRAPH for ZRT2

ZRT2 encodes a low-affinity zinc transporter (3). There are two systems for zinc uptake in yeast, one high-affinity and one lower-affinity (3). Zrt2p and the high-affinity zinc transporter Zrt1p are similar to each other, and are members of the ZIP family of heavy metal ion transporters (4). Zap1p is a transcriptional regulator that controls levels of ZRT1 and ZRT2 mRNAs in response to intracellular zinc levels (2).

Last updated: 2000-05-01 Contact SGD

References cited on this page View Complete Literature Guide for ZRT2
1) Zhao H and Eide D  (1996) The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae. J Biol Chem 271(38):23203-10
2) Zhao H and Eide DJ  (1997) Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol Cell Biol 17(9):5044-52
3) Zhao H and Eide D  (1996) The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation. Proc Natl Acad Sci U S A 93(6):2454-8
4) Eng BH, et al.  (1998) Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins. J Membr Biol 166(1):1-7