COQ5/YML110C Summary

COQ5 BASIC INFORMATION

Standard Name	COQ5
Systematic Name	YML110C
Alias	DBI56
Feature Type	ORF, Verified
Description	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes (1, 2, 3)
Name Description	COenzyme Q
Gene Product Alias	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase 1

GO Annotations	All COQ5 GO evidence and references
	View Computational GO annotations for COQ5
Molecular Function
Manually curated	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity (IMP, ISS)
Biological Process
Manually curated	aerobic respiration (IMP) ubiquinone biosynthetic process (IMP)
Cellular Component
Manually curated	mitochondrial matrix (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of ubiquinone biosynthesis ubiquinone biosynthesis

Mutant Phenotype	All COQ5 Phenotype details and references
Classical genetics
null	respiratory growth: absent
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased resistance to ethanol: decreased respiratory growth: decreased rate respiratory growth: absent utilization of carbon source: decreased viable

Interactions	COQ5 All interactions details and references
	12 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 Reconstituted Complex: 1 Two-hybrid: 6
Genetic Interactions	Synthetic Growth Defect: 2

Sequence Information

ChrXIII:50954 to 50031 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..924	50954..50031	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004578

COQ5 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for COQ5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for COQ5]

1)	Dibrov E, et al. (1997) The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain. J Biol Chem 272(14):9175-81
2)	Barkovich RJ, et al. (1997) Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis. J Biol Chem 272(14):9182-8
3)	Hsieh EJ, et al. (2007) Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex. Arch Biochem Biophys 463(1):19-26

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