ABD1/YBR236C Summary

ABD1 BASIC INFORMATION

Standard Name	ABD1
Systematic Name	YBR236C
Feature Type	ORF, Verified
Description	Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA (1, 2)

GO Annotations	All ABD1 GO evidence and references
	View Computational GO annotations for ABD1
Molecular Function
Manually curated	mRNA (guanine-N7-)-methyltransferase activity (IDA, ISS)
Biological Process
Manually curated	mRNA capping (IDA)
Cellular Component
Manually curated	DNA-directed RNA polymerase II, holoenzyme (IPI) nucleus (IPI)

Mutant Phenotype	All ABD1 Phenotype details and references
Classical genetics
conditional	heat sensitivity: increased
null	inviable
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable resistance to St. John's Wort extract: decreased

Interactions	ABD1 All interactions details and references
	18 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 3 Phenotypic Enhancement: 4 Synthetic Lethality: 2

Sequence Information

ChrII:691688 to 690378 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1311	691688..690378	2004-07-16	1997-01-28

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000440

ABD1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ABD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ABD1]

1)	Mao X, et al. (1995) Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. Mol Cell Biol 15(8):4167-74
2)	Schwer B, et al. (2000) Structure-function analysis of yeast mRNA cap methyltransferase and high-copy suppression of conditional mutants by AdoMet synthase and the ubiquitin conjugating enzyme Cdc34p. Genetics 155(4):1561-76

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