HMT1/YBR034C Summary

HMT1 BASIC INFORMATION

Standard Name	HMT1
Systematic Name	YBR034C
Alias	HCP1 , ODP1 , RMT1
Feature Type	ORF, Verified
Description	Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; also methylates ribosomal protein Rps2p (1, 2, 3, 4, 5)
Name Description	HnRNP MethylTransferase 1

GO Annotations	All HMT1 GO evidence and references
	View Computational GO annotations for HMT1
Molecular Function
Manually curated	protein-arginine N-methyltransferase activity (IDA, IPI, ISS)
Biological Process
Manually curated	mRNA export from nucleus (IGI) negative regulation of transcription termination (IMP) peptidyl-arginine modification (IDA, ISS) positive regulation of gene-specific transcription elongation from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Mutant Phenotype	All HMT1 Phenotype details and references
Classical genetics
null	mitotic recombination: increased silencing: decreased
overexpression	mitotic recombination: decreased
Large-scale survey
null	sporulation: decreased viable
overexpression	resistance to rapamycin: increased

Interactions	HMT1 All interactions details and references
	68 total interaction(s) for 41 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-Western: 4 Biochemical Activity: 20 Co-crystal Structure: 1 Co-fractionation: 1 Reconstituted Complex: 2 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 11 Phenotypic Suppression: 9 Synthetic Growth Defect: 1 Synthetic Lethality: 8 Synthetic Rescue: 1

Sequence Information

ChrII:305976 to 304930 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1047	305976..304930	2004-07-16	1997-01-28

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000238

HMT1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HMT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HMT1]

1)	Henry MF and Silver PA (1996) A novel methyltransferase (Hmt1p) modifies poly(A)+-RNA-binding proteins. Mol Cell Biol 16(7):3668-78
2)	Shen EC, et al. (1998) Arginine methylation facilitates the nuclear export of hnRNP proteins. Genes Dev 12(5):679-91
3)	Gary JD, et al. (1996) The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae. J Biol Chem 271(21):12585-94
4)	Lipson RS, et al. (2010) Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae. Biochem Biophys Res Commun 391(4):1658-62
5)	Wong CM, et al. (2010) Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p. Nucleic Acids Res ()

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