UBP8/YMR223W Summary Help

Standard Name UBP8 1
Systematic Name YMR223W
Feature Type ORF, Verified
Description Ubiquitin-specific protease component of the SAGA acetylation complex; required for SAGA (Spt-Ada-Gcn5-Acetyltransferase)-mediated deubiquitination of histone H2B (2, 3)
Name Description UBiquitin-specific processing Protease 1
Chromosomal Location
ChrXIII:716715 to 718130 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All UBP8 GO evidence and references
  View Computational GO annotations for UBP8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
578 total interaction(s) for 283 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 201
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 34
  • Biochemical Activity: 8
  • Co-crystal Structure: 1
  • Co-localization: 3
  • Co-purification: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 136
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 7
  • Positive Genetic: 73
  • Synthetic Growth Defect: 18
  • Synthetic Lethality: 12
  • Synthetic Rescue: 74

Resources
Expression Summary
histogram
Resources
Length (a.a.) 471
Molecular Weight (Da) 53,623
Isoelectric Point (pI) 7.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:716715 to 718130 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1416 716715..718130 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004836
References cited on this page View Complete Literature Guide for UBP8
1) Amerik AY, et al.  (2000) Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae. Biol Chem 381(9-10):981-92
2) Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39
3) Henry KW, et al.  (2003) Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev 17(21):2648-63