tL(UAA)Q Summary Help

Systematic Name tL(UAA)Q
Feature Type tRNA
Description Mitochondrial leucine tRNA (tRNA-Leu); predicted by tRNAscan-SE analysis; required for mitochondrial translation and indirectly for maintenance of the mitochondrial genome; mutations in the orthologous human gene cause the neurological disease MELAS (1, 2, 3)
Chromosomal Location
ChrMito:66095 to 66179 | ORF Map | GBrowse
Gene Ontology Annotations All tL(UAA)Q GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
reduction of function
2 total interaction(s) for 1 unique genes/features.
Physical Interactions
  • Protein-RNA: 1

Genetic Interactions
  • Dosage Rescue: 1

sequence information
ChrMito:66095 to 66179 | ORF Map | GBrowse
Last Update Coordinates: 2000-05-19 | Sequence: 2000-05-19
Subfeature details
Most Recent Updates
Coordinates Sequence
Noncoding exon 1..85 66095..66179 2000-05-19 2000-05-19
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
External Links All Associated Seq | Search all NCBI (Entrez)
Primary SGDIDS000007324
References cited on this page View Complete Literature Guide for tL(UAA)Q
1) Foury F, et al.  (1998) The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS Lett 440(3):325-31
2) Feuermann M, et al.  (2003) The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Rep 4(1):53-8
3) Chan PP and Lowe TM  (2009) GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Nucleic Acids Res 37(Database issue):D93-7