SSO1/YPL232W Summary Help

Standard Name SSO1
Systematic Name YPL232W
Feature Type ORF, Verified
Description Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Chromosomal Location
ChrXVI:107275 to 108147 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SSO1 GO evidence and references
  View Computational GO annotations for SSO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 119 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
unspecified
Resources
160 total interaction(s) for 71 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 33
  • Biochemical Activity: 3
  • Co-crystal Structure: 2
  • Co-fractionation: 2
  • FRET: 3
  • PCA: 3
  • Reconstituted Complex: 22
  • Two-hybrid: 33

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 5
  • Dosage Rescue: 16
  • Negative Genetic: 16
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 2
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 290
Molecular Weight (Da) 33,106
Isoelectric Point (pI) 5.06
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:107275 to 108147 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..873 107275..108147 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006153
References cited on this page View Complete Literature Guide for SSO1
1) Aalto MK, et al.  (1993) Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport. EMBO J 12(11):4095-104
2) Nicholson KL, et al.  (1998) Regulation of SNARE complex assembly by an N-terminal domain of the t-SNARE Sso1p. Nat Struct Biol 5(9):793-802
3) Jantti J, et al.  (2002) Characterization of temperature-sensitive mutations in the yeast syntaxin 1 homologues Sso1p and Sso2p, and evidence of a distinct function for Sso1p in sporulation. J Cell Sci 115(Pt 2):409-20
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Nakanishi H, et al.  (2006) Phospholipase D and the SNARE Sso1p are necessary for vesicle fusion during sporulation in yeast. J Cell Sci 119(Pt 7):1406-15