SKN7/YHR206W Summary Help

SKN7 BASIC INFORMATION

Standard Name SKN7 1
Systematic Name YHR206W
Alias BRY1 2 , POS9 3
Feature Type ORF, Verified
Description Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation (4, 5, 6)
Name Description Suppressor of Kre Null 7
GO Annotations All SKN7 GO evidence and references
    View Computational GO annotations for SKN7
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs SKN7 Transcription Factor Binding Sites and References
  • ATTTGGCYGGSCC
  • GNCNNGSCS
Mutant Phenotype All SKN7 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions SKN7 All interactions details and references
85 total interaction(s) for 61 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Biochemical Activity: 5
  • Protein-peptide: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 8
  • Phenotypic Enhancement: 17
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 3
  • Synthetic Rescue: 7
Sequence Information
ChrVIII:512732 to 514600 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1869 512732..514600 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001249

SKN7 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SKN7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SKN7]

1) Brown JL, et al.  (1993) SKN7, a yeast multicopy suppressor of a mutation affecting cell wall beta-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors. J Bacteriol 175(21):6908-15
2) Morgan BA, et al.  (1995) A yeast transcription factor bypassing the requirement for SBF and DSC1/MBF in budding yeast has homology to bacterial signal transduction proteins. EMBO J 14(22):5679-89
3) Krems B, et al.  (1996) The response regulator-like protein Pos9/Skn7 of Saccharomyces cerevisiae is involved in oxidative stress resistance. Curr Genet 29(4):327-34
4) Raitt DC, et al.  (2000) The Skn7 response regulator of Saccharomyces cerevisiae interacts with Hsf1 in vivo and is required for the induction of heat shock genes by oxidative stress. Mol Biol Cell 11(7):2335-47
5) Ikner A and Shiozaki K  (2005) Yeast signaling pathways in the oxidative stress response. Mutat Res 569(1-2):13-27
6) Janiak-Spens F, et al.  (2005) Kinetic analysis of YPD1-dependent phosphotransfer reactions in the yeast osmoregulatory phosphorelay system. Biochemistry 44(1):377-86
7) Roemer T, et al.  (1993) SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis. Mol Cell Biol 13(7):4039-48