SHQ1/YIL104C Summary Help

Standard Name SHQ1 1
Systematic Name YIL104C
Feature Type ORF, Verified
Description Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; relocalizes to the cytosol in response to hypoxia (1, 2, 3, 4)
Name Description Small nucleolar RNAs of the box H/ACA family Quantitative accumulation 1
Chromosomal Location
ChrIX:171505 to 169982 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SHQ1 GO evidence and references
  View Computational GO annotations for SHQ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
repressible
Large-scale survey
conditional
null
overexpression
reduction of function
unspecified
Resources
31 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Co-crystal Structure: 4
  • Co-purification: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 1
  • Positive Genetic: 2
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 507
Molecular Weight (Da) 59,150
Isoelectric Point (pI) 4.55
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:171505 to 169982 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1524 171505..169982 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001366
References cited on this page View Complete Literature Guide for SHQ1
1) Yang PK, et al.  (2002) The Shq1p.Naf1p complex is required for box H/ACA small nucleolar ribonucleoprotein particle biogenesis. J Biol Chem 277(47):45235-42
2) Godin KS, et al.  (2009) The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme. J Mol Biol 390(2):231-44
3) Walbott H, et al.  (2011) The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. Genes Dev 25(22):2398-408
4) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30