SGF29/YCL010C Summary Help

Standard Name SGF29 1
Systematic Name YCL010C
Feature Type ORF, Verified
Description Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation (1, 2, 3, 4)
Name Description SaGa associated Factor 1
Chromosomal Location
ChrIII:104350 to 103571 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SGF29 GO evidence and references
  View Computational GO annotations for SGF29
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
410 total interaction(s) for 265 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 227
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 11
  • Biochemical Activity: 2
  • Co-crystal Structure: 2
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 117
  • Positive Genetic: 24
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 259
Molecular Weight (Da) 29,381
Isoelectric Point (pI) 5.23
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:104350 to 103571 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2006-01-12 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..780 104350..103571 2006-01-12 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000516
References cited on this page View Complete Literature Guide for SGF29
1) Sanders SL, et al.  (2002) Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol Cell Biol 22(13):4723-38
2) Bian C, et al.  (2011) Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.LID - 10.1038/emboj.2011.193 [doi] EMBO J ()
3) Lee KK, et al.  (2011) Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. Mol Syst Biol 7():503
4) Shukla A, et al.  (2012) Sgf29p facilitates the recruitment of TATA box binding protein but does not alter SAGA's global structural integrity in vivo. Biochemistry 51(2):706-14