SEC4/YFL005W Summary Help

SEC4 BASIC INFORMATION

Standard Name SEC4 1, 2
Systematic Name YFL005W
Alias SRO6
Feature Type ORF, Verified
Description Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane (3)
Name Description SECretory 4
GO Annotations All SEC4 GO evidence and references
    View Computational GO annotations for SEC4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SEC4 Phenotype details and references
Classical genetics
conditional
null
reduction of function
unspecified
Large-scale survey
null
overexpression
repressible
Interactions SEC4 All interactions details and references
147 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 18
  • Biochemical Activity: 7
  • Co-crystal Structure: 3
  • Co-fractionation: 1
  • Co-purification: 2
  • PCA: 6
  • Reconstituted Complex: 7
  • Two-hybrid: 10
Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 3
  • Dosage Rescue: 26
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 43
  • Synthetic Rescue: 2
Sequence Information
ChrVI:130329 to 130976 | ORF Map | GBrowse
Gbrowse
Genetic position: -6 cM
Last Update Coordinates: 2003-09-26 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..648 130329..130976 2003-09-26 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001889

SEC4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SEC4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC4]

1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Fields, C. and Schekman, R.  (1985) Personal Communication, Mortimer Map Edition 9
3) Guo W, et al.  (1999) The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J 18(4):1071-80
4) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62