RIF1/YBR275C Summary Help

Standard Name RIF1 1
Systematic Name YBR275C
Feature Type ORF, Verified
Description Protein that binds to the Rap1p C-terminus; acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; contributes to resection of DNA double strand breaks (DSBs); deletion results in telomere elongation (2, 3, 4, 5)
Name Description RAP1-Interacting Factor 1
Chromosomal Location
ChrII:757106 to 751356 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RIF1 GO evidence and references
  View Computational GO annotations for RIF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 359 genes
Regulators 105 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
97 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 28
  • Phenotypic Enhancement: 15
  • Phenotypic Suppression: 9
  • Positive Genetic: 2
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 2
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,916
Molecular Weight (Da) 217,930
Isoelectric Point (pI) 6.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:757106 to 751356 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..5751 757106..751356 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000479
References cited on this page View Complete Literature Guide for RIF1
1) Hardy CF, et al.  (1992) A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 6(5):801-14
2) Wotton D and Shore D  (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11(6):748-60
3) Teixeira MT, et al.  (2004) Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell 117(3):323-35
4) Smogorzewska A and de Lange T  (2004) Regulation of telomerase by telomeric proteins. Annu Rev Biochem 73:177-208
5) Martina M, et al.  (2014) Saccharomyces cerevisiae Rif1 cooperates with MRX-Sae2 in promoting DNA-end resection. EMBO Rep ()