RGS2/YOR107W Summary

RGS2 BASIC INFORMATION

Standard Name	RGS2
Systematic Name	YOR107W
Feature Type	ORF, Verified
Description	Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p (1)
Name Description	Regulator of heterotrimeric G protein Signaling 1

GO Annotations	All RGS2 GO evidence and references
	View Computational GO annotations for RGS2
Molecular Function
Manually curated	GTPase activator activity (IDA)
Biological Process
Manually curated	G-protein signaling, coupled to cAMP nucleotide second messenger (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All RGS2 Phenotype details and references
Classical genetics
null	mating efficiency: increased
Large-scale survey
null	budding index: increased replicative lifespan: increased viable

Interactions	RGS2 All interactions details and references
	7 total interaction(s) for 7 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 4 Reconstituted Complex: 1

Sequence Information

ChrXV:521354 to 522283 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..930	521354..522283	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005633

RGS2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RGS2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RGS2]

1)	Versele M, et al. (1999) A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J 18(20):5577-91

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