PHO23/YNL097C Summary Help

Standard Name PHO23
Systematic Name YNL097C
Feature Type ORF, Verified
Description Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 (1, 2, 3, 4, 5, 6)
Name Description PHOsphate metabolism
Chromosomal Location
ChrXIV:442358 to 441366 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PHO23 GO evidence and references
  View Computational GO annotations for PHO23
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
953 total interaction(s) for 508 unique genes/features.
Physical Interactions
  • Affinity Capture-Luminescence: 4
  • Affinity Capture-MS: 53
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 14
  • Biochemical Activity: 2
  • Co-localization: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 2
  • Negative Genetic: 596
  • Phenotypic Enhancement: 15
  • Phenotypic Suppression: 11
  • Positive Genetic: 133
  • Synthetic Growth Defect: 85
  • Synthetic Lethality: 19
  • Synthetic Rescue: 13

Resources
Expression Summary
histogram
Resources
Length (a.a.) 330
Molecular Weight (Da) 37,024
Isoelectric Point (pI) 7.71
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:442358 to 441366 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YNL097W-A
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..993 442358..441366 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005041
References cited on this page View Complete Literature Guide for PHO23
1) Lau WW, et al.  (1998) A genetic study of signaling processes for repression of PHO5 transcription in Saccharomyces cerevisiae. Genetics 150(4):1349-59
2) Loewith R, et al.  (2000) Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol Cell Biol 20(11):3807-16
3) Loewith R, et al.  (2001) Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae. J Biol Chem 276(26):24068-74
4) Carrozza MJ, et al.  (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6
5) Gordon PM, et al.  (2008) Interspecies data mining to predict novel ING-protein interactions in human. BMC Genomics 9:426
6) Terzi N, et al.  (2011) H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol 31(17):3569-83