Standard Name	PAB1
Systematic Name	YER165W
Feature Type	ORF, Verified
Description	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G (1, 2, 3)
Name Description	Poly(A) Binding protein 4

Chromosomal Location	ChrV:510373 to 512106 | ORF Map | GBrowse

	View Computational GO annotations for PAB1
Molecular Function
Manually curated	poly(A) RNA binding (IDA, IMP)
Biological Process
Manually curated	regulation of nuclear-transcribed mRNA poly(A) tail shortening (IDA, IMP) regulation of translational initiation (IDA, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) cytoplasmic stress granule (IDA) nucleus (IDA) ribosome (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	inviable
reduction of function	heat sensitivity: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient heat sensitivity: increased inviable
overexpression	colony sectoring: increased vegetative growth: decreased rate
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	351 total interaction(s) for 224 unique genes/features.
Physical Interactions	Affinity Capture-MS: 195 Affinity Capture-RNA: 4 Affinity Capture-Western: 48 Biochemical Activity: 4 Co-fractionation: 1 Co-localization: 1 Co-purification: 1 Reconstituted Complex: 20 Two-hybrid: 11
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 12 Negative Genetic: 20 Positive Genetic: 9 Synthetic Growth Defect: 1 Synthetic Lethality: 5 Synthetic Rescue: 17
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:510373 to 512106 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1734 510373..512106 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000967