MTM1/YGR257C Summary

MTM1 BASIC INFORMATION

Standard Name	MTM1
Systematic Name	YGR257C
Feature Type	ORF, Verified
Description	Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor (1)
Name Description	Manganese Trafficking factor for Mitochondrial SOD2 1

GO Annotations	All MTM1 GO evidence and references
	View Computational GO annotations for MTM1
Molecular Function
Manually curated	metallochaperone activity (IMP) transporter activity (ISS)
Biological Process
Manually curated	manganese ion transport (IMP) transport (ISS)
Cellular Component
Manually curated	mitochondrial inner membrane (ISS) mitochondrion (IDA)

Mutant Phenotype	All MTM1 Phenotype details and references
Classical genetics
null	iron accumulation: increased Sod2p activity: decreased
Large-scale survey
null	competitive fitness: decreased oxidative stress resistance: decreased resistance to hydroxyurea: decreased respiratory growth: decreased rate respiratory growth: absent

Interactions	MTM1 All interactions details and references
	5 total interaction(s) for 5 unique genes/features.
Physical Interactions	Biochemical Activity: 1 Two-hybrid: 1
Genetic Interactions	Synthetic Growth Defect: 1 Synthetic Lethality: 2

Sequence Information

ChrVII:1007311 to 1006211 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-29 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1101	1007311..1006211	2005-11-29	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003489

MTM1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MTM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MTM1]

1)	Luk E, et al. (2003) Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family. Proc Natl Acad Sci U S A 100(18):10353-7

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