MFA1/YDR461W Summary Help

Standard Name MFA1
Systematic Name YDR461W
Feature Type ORF, Verified
Description Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 (1, 2)
Name Description Mating Factor A
Chromosomal Location
ChrIV:1385176 to 1385286 | ORF Map | GBrowse
Gbrowse
Genetic position: 280.27 cM
Gene Ontology Annotations All MFA1 GO evidence and references
  View Computational GO annotations for MFA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 17 genes
Resources
Classical genetics
reduction of function
unspecified
Large-scale survey
null
Resources
9 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 4
  • Co-purification: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 36
Molecular Weight (Da) 3,926
Isoelectric Point (pI) 8.41
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1385176 to 1385286 | ORF Map | GBrowse
SGD ORF map
Genetic position: 280.27 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..111 1385176..1385286 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002869
References cited on this page View Complete Literature Guide for MFA1
1) Chen P, et al.  (1997) Biogenesis of the Saccharomyces cerevisiae mating pheromone a-factor. J Cell Biol 136(2):251-69
2) Michaelis S and Herskowitz I  (1988) The a-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol Cell Biol 8(3):1309-18