MET2/YNL277W Summary Help

Standard Name MET2 1
Systematic Name YNL277W
Feature Type ORF, Verified
Description L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway (2, 3)
Name Description METhionine requiring 1
Chromosomal Location
ChrXIV:117349 to 118809 | ORF Map | GBrowse
Gbrowse
Genetic position: -187 cM
Gene Ontology Annotations All MET2 GO evidence and references
  View Computational GO annotations for MET2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 7 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
11 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 5
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 486
Molecular Weight (Da) 53,659
Isoelectric Point (pI) 5.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:117349 to 118809 | ORF Map | GBrowse
SGD ORF map
Genetic position: -187 cM
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1461 117349..118809 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005221
References cited on this page View Complete Literature Guide for MET2
1) Masselot M and De Robichon-Szulmajster H  (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32
2) Forlani N, et al.  (1991) Posttranscriptional regulation of the expression of MET2 gene of Saccharomyces cerevisiae. Biochim Biophys Acta 1089(1):47-53
3) Hansen J and Kielland-Brandt MC  (1996) Inactivation of MET2 in brewer's yeast increases the level of sulfite in beer. J Biotechnol 50(1):75-87