MET17/YLR303W Summary

MET17 BASIC INFORMATION

Standard Name	MET17 1
Systematic Name	YLR303W
Alias	MET15 , MET25
Feature Type	ORF, Verified
Description	Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis (2, 3)
Name Description	METhionine requiring 1

GO Annotations	All MET17 GO evidence and references
	View Computational GO annotations for MET17
Molecular Function
Manually curated	cysteine synthase activity (IDA) O-acetylhomoserine aminocarboxypropyltransferase activity (IDA, TAS)
Biological Process
Manually curated	cysteine biosynthetic process (TAS) methionine metabolic process (IMP) response to toxin (IEP)
High-throughput	response to drug (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) plasma membrane enriched fraction (IDA)

Pathways	homocysteine biosynthesis superpathway of methionine biosynthesis superpathway of sulfur amino acid biosynthesis superpathway of threonine and methionine biosynthesis

Mutant Phenotype	All MET17 Phenotype details and references
Classical genetics
null	auxotrophy metal resistance: increased
Large-scale survey
null	competitive fitness: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased viable

Interactions	MET17 All interactions details and references
	15 total interaction(s) for 15 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 1 Biochemical Activity: 5
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 1

Sequence Information

ChrXII:732544 to 733878 | |

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1335	732544..733878	2004-02-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004294

MET17 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for MET17

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MET17]

1)	Masselot M and De Robichon-Szulmajster H (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32
2)	Yamagata S, et al. (1994) Overexpression of the Saccharomyces cerevisiae MET17/MET25 gene in Escherichia coli and comparative characterization of the product with O-acetylserine.O-acetylhomoserine sulfhydrylase of the yeast. Appl Microbiol Biotechnol 42(1):92-9
3)	Brzywczy J and Paszewski A (1993) Role of O-acetylhomoserine sulfhydrylase in sulfur amino acid synthesis in various yeasts. Yeast 9(12):1335-42

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