IMD2/YHR216W Summary Help

IMD2 BASIC INFORMATION

Standard Name IMD2 1
Systematic Name YHR216W
Alias PUR5 2
Feature Type ORF, Verified
Description Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio (1, 3, 4, 5)
Name Description IMP Dehydrogenase 1
GO Annotations All IMD2 GO evidence and references
    View Computational GO annotations for IMD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Pathways
Mutant Phenotype All IMD2 Phenotype details and references
Classical genetics
null
overexpression
unspecified
Interactions IMD2 All interactions details and references
43 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 2
  • Co-purification: 1
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 5
Sequence Information
ChrVIII:554396 to 555967 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1572 554396..555967 2005-11-07 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001259

IMD2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for IMD2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IMD2]

1) Escobar-Henriques M and Daignan-Fornier B  (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30
2) Shaw RJ and Reines D  (2000) Saccharomyces cerevisiae transcription elongation mutants are defective in PUR5 induction in response to nucleotide depletion. Mol Cell Biol 20(20):7427-37
3) Shaw RJ, et al.  (2001) Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast. J Biol Chem 276(35):32905-16
4) Hyle JW, et al.  (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8
5) Escobar-Henriques M, et al.  (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90