FOL3/YMR113W Summary Help

Standard Name FOL3 1
Systematic Name YMR113W
Feature Type ORF, Verified
Description Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication (1, 2, 3)
Name Description FOLic acid synthesis 1
Chromosomal Location
ChrXIII:494999 to 496282 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FOL3 GO evidence and references
  View Computational GO annotations for FOL3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 2 genes
Resources
Pathways
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
reduction of function
Resources
7 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3

Genetic Interactions
  • Dosage Lethality: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 427
Molecular Weight (Da) 47,851
Isoelectric Point (pI) 6.81
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:494999 to 496282 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1284 494999..496282 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004719
References cited on this page View Complete Literature Guide for FOL3
1) Cherest H, et al.  (2000) Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae. J Biol Chem 275(19):14056-63
2) Bayly AM, et al.  (2001) Folic acid utilisation related to sulfa drug resistance in Saccharomyces cerevisiae. FEMS Microbiol Lett 204(2):387-90
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61