FLO8/YER109C Summary Help

Standard Name FLO8 1, 2
Systematic Name YER109C
Alias PHD5 3 , YER108C , STA10 4
Feature Type ORF, Verified
Description Transcription factor; required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a nonsense mutation in this gene (1, 2, 5)
Name Description FLOcculation
Chromosomal Location
ChrV:377614 to 375215 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All FLO8 GO evidence and references
  View Computational GO annotations for FLO8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 30 genes
Regulators 5 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
62 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3

Genetic Interactions
  • Dosage Rescue: 20
  • Negative Genetic: 8
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 18
  • Positive Genetic: 3
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 798
Molecular Weight (Da) 86,648
Isoelectric Point (pI) 10.12
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:377614 to 375215 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2400 377614..375215 2011-02-03 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000911
References cited on this page View Complete Literature Guide for FLO8
1) Kobayashi O, et al.  (1996) Molecular cloning and analysis of the dominant flocculation gene FLO8 from Saccharomyces cerevisiae. Mol Gen Genet 251(6):707-15
2) Liu H, et al.  (1996) Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth. Genetics 144(3):967-78
3) Gimeno CJ and Fink GR  (1994) Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Mol Cell Biol 14(3):2100-12
4) Kim TS, et al.  (2003) STA10 repression of STA gene expression is caused by a defective activator, flo8, in Saccharomyces cerevisiae. Curr Genet 44(5):261-7
5) Rupp S, et al.  (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18(5):1257-69