ERG7/YHR072W Summary 
| Standard Name | ERG7 1, 2 |
|---|---|
| Systematic Name | YHR072W |
| Feature Type | ORF, Verified |
| Description | Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis (3, 4, 5, 6, 7 and see Summary Paragraph) |
| Name Description | ERGosterol biosynthesis 1 |
| Chromosomal Location | |
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Gene Ontology Annotations All ERG7 GO evidence and references
| View Computational GO annotations for ERG7 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
| Pathways |
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Mutant phenotypes All ERG7 Phenotype evidence and references
| Classical genetics | |
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| gain of function | |
| null | |
| Large-scale survey | |
| null | |
| repressible | |
| Resources |
interactions All ERG7 Interaction evidence and references
| 48 total interaction(s) for 27 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All ERG7 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 2011-02-03 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000001114 |
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SUMMARY PARAGRAPH for ERG7
ERG7 encodes lanosterol synthase, which catalyzes the cyclization of squalene 2,3-epoxide, a step in the biosynthesis of ergosterol (6, 5, 7, 3, 4). Deletion of ERG7 is lethal; an erg7 hem1 (heme-deficient) mutant is auxotrophic for sterols (8). The erg7 null phenotype can be suppressed by expression of the Candida albicans ERG7 gene(9). Expression of ERG9, which encodes farnesyl-diphosphate farnesy l transferase, is increased in erg7 mutants (10).
Last updated: 2005-06-29 
References cited on this page View Complete Literature Guide for ERG7
| 1) | Karst F and Lacroute F (1977) Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. Mol Gen Genet 154(3):269-77 |
| 2) | Griffin, J.H. et al. (1996) Mutations in the Oxidosqualene-Lanosterol Cyclase gene of Saccharomyces cerevisiae. Unpublished |
| 3) | Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6 |
| 4) | Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 |
| 5) | Shi Z, et al. (1994) Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 91(15):7370-4 |
| 6) | Corey EJ, et al. (1994) Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase. Proc Natl Acad Sci U S A 91(6):2211-5 |
| 7) | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
| 8) | Lewis TA, et al. (1985) Involvement of heme biosynthesis in control of sterol uptake by Saccharomyces cerevisiae. J Bacteriol 163(1):199-207 |
| 9) | Kelly R, et al. (1990) Cloning and characterization of the 2,3-oxidosqualene cyclase-coding gene of Candida albicans. Gene 87(2):177-83 |
| 10) | Kennedy MA, et al. (1999) Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1445(1):110-22 |
