ERG5/YMR015C Summary 
| Standard Name | ERG5 |
|---|---|
| Systematic Name | YMR015C |
| Alias | CYP61 1 |
| Feature Type | ORF, Verified |
| Description | C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs (2, 3, 4, 5 and see Summary Paragraph) |
| Name Description | ERGosterol biosynthesis |
| Chromosomal Location | |
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| Note: this feature is encoded on the Crick strand. | |
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Gene Ontology Annotations All ERG5 GO evidence and references
| View Computational GO annotations for ERG5 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| High-throughput |
| Pathways |
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Mutant phenotypes All ERG5 Phenotype evidence and references
interactions All ERG5 Interaction evidence and references
| 250 total interaction(s) for 144 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All ERG5 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000004617 |
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SUMMARY PARAGRAPH for ERG5
ERG5 encodes C-22 sterol desaturase, a cytochrome P-450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis (4, 6, 5, 2, 3). Cells lacking ERG5 are viable (6); an erg5 mutation increases ERG3 expression (7). Erg5p binds, and may be a target of, azole antifungal drugs (1). An ERG5 homolog has been identified in Candida glabrata (8).
Last updated: 2000-09-06 
References cited on this page View Complete Literature Guide for ERG5
| 1) | Kelly SL, et al. (1997) Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents. J Biol Chem 272(15):9986-8 |
| 2) | Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6 |
| 3) | Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 |
| 4) | Kelly SL, et al. (1995) Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol delta 22-desaturase. FEBS Lett 377(2):217-20 |
| 5) | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
| 6) | Skaggs BA, et al. (1996) Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis. Gene 169(1):105-9 |
| 7) | Arthington-Skaggs BA, et al. (1996) Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. FEBS Lett 392(2):161-5 |
| 8) | Lamb DC, et al. (1999) Purification, reconstitution, and inhibition of cytochrome P-450 sterol delta22-desaturase from the pathogenic fungus Candida glabrata. Antimicrob Agents Chemother 43(7):1725-8 |
