CTF4/YPR135W Summary Help

Standard Name CTF4 1
Systematic Name YPR135W
Alias CHL15 , POB1
Feature Type ORF, Verified
Description Chromatin-associated protein; required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion (2, 3)
Name Description Chromosome Transmission Fidelity 1
Chromosomal Location
ChrXVI:799234 to 802017 | ORF Map | GBrowse
Gbrowse
Genetic position: 103 cM
Gene Ontology Annotations All CTF4 GO evidence and references
  View Computational GO annotations for CTF4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
734 total interaction(s) for 359 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 28
  • Biochemical Activity: 4
  • Co-purification: 5
  • Protein-peptide: 3
  • Reconstituted Complex: 10
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 2
  • Dosage Rescue: 2
  • Negative Genetic: 177
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 4
  • Positive Genetic: 20
  • Synthetic Growth Defect: 287
  • Synthetic Lethality: 147
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 927
Molecular Weight (Da) 104,424
Isoelectric Point (pI) 4.96
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:799234 to 802017 | ORF Map | GBrowse
SGD ORF map
Genetic position: 103 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2784 799234..802017 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006339
References cited on this page View Complete Literature Guide for CTF4
1) Spencer F, et al.  (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49
2) Miles J and Formosa T  (1992) Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo. Mol Cell Biol 12(12):5724-35
3) Hanna JS, et al.  (2001) Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. Mol Cell Biol 21(9):3144-58