Standard Name	CSE4 1
Systematic Name	YKL049C
Alias	CSL2 2
Feature Type	ORF, Verified
Description	Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions (1, 3, 4, 5, 6)
Name Description	Chromosome SEgregation 1

Chromosomal Location	ChrXI:346764 to 346075 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CSE4
Molecular Function
Manually curated	centromeric DNA binding (IDA) sequence-specific DNA binding (IDA)
Biological Process
Manually curated	2-micrometer plasmid partitioning (IMP) mitotic sister chromatid segregation (IMP)
Cellular Component
Manually curated	centromere-specific nucleosome (IDA) condensed nuclear chromosome, centromeric region (IGI) extrachromosomal circular DNA (IDA) kinetochore (IGI) nuclear nucleosome (IDA)

Classical genetics
conditional	Cbf2p-13Myc distribution: abnormal Scm3p-3Flag distribution: abnormal
null	inviable
reduction of function	inviable
repressible	chromosome segregation: abnormal
Large-scale survey
conditional	colony sectoring: increased
null	haploinsufficient inviable
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: normal resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	446 total interaction(s) for 351 unique genes/features.
Physical Interactions	Affinity Capture-MS: 314 Affinity Capture-Western: 34 Biochemical Activity: 2 Co-crystal Structure: 1 Co-localization: 10 Reconstituted Complex: 5 Two-hybrid: 6
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 9 Dosage Rescue: 12 Negative Genetic: 2 Phenotypic Suppression: 4 Synthetic Growth Defect: 27 Synthetic Lethality: 16 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:346764 to 346075 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-01-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..690 346764..346075 2011-02-03 2003-01-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001532