CDC8/YJR057W Summary

CDC8 BASIC INFORMATION

Standard Name	CDC8
Systematic Name	YJR057W
Feature Type	ORF, Verified
Description	Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p (1, 2)
Name Description	Cell Division Cycle 3

GO Annotations	All CDC8 GO evidence and references
	View Computational GO annotations for CDC8
Molecular Function
Manually curated	thymidylate kinase activity (IDA) uridylate kinase activity (IDA)
Biological Process
Manually curated	DNA repair (IMP) DNA-dependent DNA replication (IDA, IMP) dTDP biosynthetic process (IDA) dTTP biosynthetic process (IDA) dUDP biosynthetic process (IDA) plasmid maintenance (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Pathways	de novo biosynthesis of pyrimidine deoxyribonucleotides

Mutant Phenotype	All CDC8 Phenotype details and references
Classical genetics
conditional	cell cycle progression: arrested cellular morphology: abnormal heat sensitivity: increased
Large-scale survey
null	inviable resistance to sulfanilamide: decreased
overexpression	filamentous growth: increased
repressible	cell cycle progression in S phase: abnormal

Interactions	CDC8 All interactions details and references
	36 total interaction(s) for 36 unique genes/features.
Physical Interactions	Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Synthetic Lethality: 29 Synthetic Rescue: 1

Sequence Information

ChrX:544054 to 544704 | |

Genetic position: 36 cM

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..651	544054..544704	2009-02-18	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003818

CDC8 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CDC8

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC8]

1)	Abaigar LT, et al. (1992) Functional and structural conservation of Schizosaccharomyces pombe dTMP kinase gene. Biochim Biophys Acta 1132(2):222-4
2)	Jong AY and Campbell JL (1984) Characterization of Saccharomyces cerevisiae thymidylate kinase, the CDC8 gene product. General properties, kinetic analysis, and subcellular localization. J Biol Chem 259(23):14394-8
3)	Hartwell LH, et al. (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.