CAN1/YEL063C Summary Help

Standard Name CAN1 1
Systematic Name YEL063C
Feature Type ORF, Verified
Description Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7)
Name Description CANavanine resistance 3
Chromosomal Location
ChrV:33466 to 31694 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -50 cM
Gene Ontology Annotations All CAN1 GO evidence and references
  View Computational GO annotations for CAN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
unspecified
Large-scale survey
null
overexpression
Resources
70 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Co-localization: 2
  • PCA: 45
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 590
Molecular Weight (Da) 65,785
Isoelectric Point (pI) 8.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:33466 to 31694 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -50 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1773 33466..31694 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000000789
References cited on this page View Complete Literature Guide for CAN1
1) Link, A. and Olson, M.  (1989) Personal Communication, Mortimer Map Edition 10
2) Ahmad M and Bussey H  (1986) Yeast arginine permease: nucleotide sequence of the CAN1 gene. Curr Genet 10(8):587-92
3) Larimer FW, et al.  (1978) Mutagenicity of methylated N-nitrosopiperidines in Saccharomyces cerevisiae. Mutat Res 57(2):155-61
4) Broach JR, et al.  (1979) Transformation in yeast: development of a hybrid cloning vector and isolation of the CAN1 gene. Gene 8(1):121-33
5) Opekarova M, et al.  (2002) Phosphatidyl ethanolamine is essential for targeting the arginine transporter Can1p to the plasma membrane of yeast. Biochim Biophys Acta 1564(1):9-13
6) Malinska K, et al.  (2003) Visualization of protein compartmentation within the plasma membrane of living yeast cells. Mol Biol Cell 14(11):4427-36
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61