AZF1/YOR113W Summary Help

Standard Name AZF1 1
Systematic Name YOR113W
Feature Type ORF, Verified
Description Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity; relocalizes to the cytosol in response to hypoxia (1, 2, 3, 4, 5, 6, 7, 8)
Name Description Asparagine-rich Zinc-Finger 1
Chromosomal Location
ChrXV:534075 to 536819 | ORF Map | GBrowse
Gene Ontology Annotations All AZF1 GO evidence and references
  View Computational GO annotations for AZF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 4 genes
Regulators 3 genes
Classical genetics
Large-scale survey
73 total interaction(s) for 63 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 7
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 47
  • Positive Genetic: 4

Expression Summary
Length (a.a.) 914
Molecular Weight (Da) 101,169
Isoelectric Point (pI) 7.35
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:534075 to 536819 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2745 534075..536819 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005639
References cited on this page View Complete Literature Guide for AZF1
1) Brohl S, et al.  (1994) A new nuclear suppressor system for a mitochondrial RNA polymerase mutant identifies an unusual zinc-finger protein and a polyglutamine domain protein in Saccharomyces cerevisiae. Yeast 10(6):719-31
2) Stein T, et al.  (1998) Azf1p is a nuclear-localized zinc-finger protein that is preferentially expressed under non-fermentative growth conditions in Saccharomyces cerevisiae. Curr Genet 34(4):287-96
3) Newcomb LL, et al.  (2002) AZF1 is a glucose-dependent positive regulator of CLN3 transcription in Saccharomyces cerevisiae. Mol Cell Biol 22(5):1607-14
4) Kucejova B and Foury F  (2003) Search for protein partners of mitochondrial single-stranded DNA-binding protein Rim1p using a yeast two-hybrid system. Folia Microbiol (Praha) 48(2):183-8
5) Slattery MG, et al.  (2006) The function and properties of the Azf1 transcriptional regulator change with growth conditions in Saccharomyces cerevisiae. Eukaryot Cell 5(2):313-20
6) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
7) Mirzaei H, et al.  (2013) Systematic measurement of transcription factor-DNA interactions by targeted mass spectrometry identifies candidate gene regulatory proteins. Proc Natl Acad Sci U S A 110(9):3645-50
8) Zampar GG, et al.  (2013) Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast. Mol Syst Biol 9():651
9) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87
10) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104