ADE1/YAR015W Summary

ADE1 BASIC INFORMATION

Standard Name	ADE1 1
Systematic Name	YAR015W
Feature Type	ORF, Verified
Description	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine (2, 3)
Name Description	ADEnine requiring 1

GO Annotations	All ADE1 GO evidence and references
	View Computational GO annotations for ADE1
Molecular Function
Manually curated	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity (IDA, IMP)
Biological Process
Manually curated	'de novo' IMP biosynthetic process (IDA, IMP) purine nucleotide biosynthetic process (IDA, IMP)
High-throughput	response to drug (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All ADE1 Phenotype details and references
Classical genetics
null	auxotrophy colony color: abnormal
Large-scale survey
null	acid pH resistance: decreased glycogen accumulation: increased polyphosphate accumulation: abnormal competitive fitness: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to ethanol: decreased viable

Interactions	ADE1 All interactions details and references
	8 total interaction(s) for 5 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Biochemical Activity: 1 Two-hybrid: 1
Genetic Interactions	Synthetic Growth Defect: 2

Sequence Information

ChrI:169370 to 170290 | |

Genetic position: 4 cM

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..921	169370..170290	2004-07-20	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000070

ADE1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for ADE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADE1]

1)	Dorfman BZ (1969) The isolation of adenylosuccinate synthetase mutants in yeast by selection for constitutive behavior in pigmented strains. Genetics 61(2):377-89
2)	Myasnikov AN, et al. (1991) The Saccharomyces cerevisiae ADE1 gene: structure, overexpression and possible regulation by general amino acid control. Gene 109(1):143-7
3)	Jones EW and Fink GR (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press

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