ZRT1/YGL255W Summary Help

Standard Name ZRT1 1
Systematic Name YGL255W
Feature Type ORF, Verified
Description High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor (1, 2 and see Summary Paragraph)
Name Description Zinc-Regulated Transporter 1
Chromosomal Location
ChrVII:20978 to 22108 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ZRT1 GO evidence and references
  View Computational GO annotations for ZRT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant phenotypes All ZRT1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
overexpression
Resources
interactions All ZRT1 Interaction evidence and references
120 total interaction(s) for 112 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 90
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 9
  • Positive Genetic: 7
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2
Resources
Expression Summary
histogram
Resources
Protein Information All ZRT1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:20978 to 22108 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1131 20978..22108 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003224
SUMMARY PARAGRAPH for ZRT1

ZRT1 encodes a high-affinity zinc transporter (1). There are two systems for zinc uptake in yeast, one high-affinity and one lower-affinity (1). Zrt1p and the lower-affinity zinc transporter Zrt2p are similar to each other, and are members of the ZIP family of heavy metal ion transporters (3). Zap1p is a transcriptional regulator that controls levels of ZRT1 and ZRT2 mRNAs in response to intracellular zinc levels (2). Levels of Zrt1p are further controlled by regulated degradation. Zrt1p is found primarily at the plasma membrane in zinc-limited cells, but is transported to the vacuole for degradation upon exposure to high levels of zinc (4).

Last updated: 2000-05-01

References cited on this page View Complete Literature Guide for ZRT1
1) Zhao H and Eide D  (1996) The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation. Proc Natl Acad Sci U S A 93(6):2454-8
2) Zhao H and Eide DJ  (1997) Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol Cell Biol 17(9):5044-52
3) Eng BH, et al.  (1998) Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins. J Membr Biol 166(1):1-7
4) Gitan RS, et al.  (1998) Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocytosis and vacuolar degradation. J Biol Chem 273(44):28617-24