ZIP2/YGL249W Summary Help

Standard Name ZIP2 1
Systematic Name YGL249W
Feature Type ORF, Verified
Description Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress (1, 2, 3)
Name Description ZIPping up meiotic chromosomes
Chromosomal Location
ChrVII:33098 to 35212 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ZIP2 GO evidence and references
  View Computational GO annotations for ZIP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
Large-scale survey
null
Resources
13 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Protein-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 4
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 704
Molecular Weight (Da) 82,815
Isoelectric Point (pI) 8.31
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:33098 to 35212 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2115 33098..35212 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003218
References cited on this page View Complete Literature Guide for ZIP2
1) Chua PR and Roeder GS  (1998) Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis. Cell 93(3):349-59
2) Agarwal S and Roeder GS  (2000) Zip3 provides a link between recombination enzymes and synaptonemal complex proteins. Cell 102(2):245-55
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76