ZIM17/YNL310C Summary Help

Standard Name ZIM17 1
Systematic Name YNL310C
Alias TIM15 2 , HEP1 3
Feature Type ORF, Verified
Description Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix (1, 3, 4)
Name Description ZInc finger Motif protein of 17 kDa 1
Chromosomal Location
ChrXIV:52431 to 51907 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ZIM17 GO evidence and references
  View Computational GO annotations for ZIM17
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Retired NameFMP28
Classical genetics
null
Large-scale survey
conditional
null
reduction of function
repressible
Resources
17 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Co-purification: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:52431 to 51907 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2006-05-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..525 52431..51907 2011-02-03 2006-05-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005254
References cited on this page View Complete Literature Guide for ZIM17
1) Burri L, et al.  (2004) Zim17, a novel zinc finger protein essential for protein import into mitochondria. J Biol Chem 279(48):50243-9
2) Yamamoto H, et al.  (2005) Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone proteins that facilitates protein translocation across the inner membrane. FEBS Lett 579(2):507-11
3) Sichting M, et al.  (2005) Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1. EMBO J 24(5):1046-56
4) Sanjuan Szklarz LK, et al.  (2005) Inactivation of the mitochondrial heat shock protein zim17 leads to aggregation of matrix hsp70s followed by pleiotropic effects on morphology and protein biogenesis. J Mol Biol 351(1):206-18