ZDS2/YML109W Summary Help

ZDS2 BASIC INFORMATION

Standard Name ZDS2 1, 2, 3, 4
Systematic Name YML109W
Alias CES4 5
Feature Type ORF, Verified
Description Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p (2, 6, 7)
Name Description Zillion Different Screens 1, 2
GO Annotations All ZDS2 GO evidence and references
    View Computational GO annotations for ZDS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All ZDS2 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions ZDS2 All interactions details and references
90 total interaction(s) for 55 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Reconstituted Complex: 2
  • Two-hybrid: 36
Genetic Interactions
  • Dosage Rescue: 8
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 7
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1
Sequence Information
ChrXIII:51640 to 54468 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2829 51640..54468 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004577

ZDS2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ZDS2

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
SSD1Nomenclature conflictMCS1 has been used to refer to both ZDS2/YML109W, whose gene product is involved in silencing, and SSD1/YDR293C, whose gene product is involved in cell wall integrity.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ZDS2]

1) Yu Y, et al.  (1996) Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression. Mol Cell Biol 16(10):5254-63
2) Bi E and Pringle JR  (1996) ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5264-75
3) Stillman, D.  (1993) Personal Communication, Mortimer Map Edition 12
4) Jiang, Y.W. and Stillman, D.J.  (1994) Personal Communication, Mortimer Map Edition 12
5) Schwer B and Shuman S  (1996) Multicopy suppressors of temperature-sensitive mutations of yeast mRNA capping enzyme. Gene Expr 5(6):331-44
6) Roy N and Runge KW  (1999) The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids. Chromosoma 108(3):146-61
7) Queralt E and Uhlmann F  (2008) Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase. J Cell Biol 182(5):873-83