ZAP1/YJL056C Summary Help

Standard Name ZAP1 1
Systematic Name YJL056C
Alias ZRG10 2
Feature Type ORF, Verified
Description Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains (1, 3, 4, 5)
Name Description Zinc-responsive Activator Protein 1
Chromosomal Location
ChrX:333073 to 330431 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ZAP1 GO evidence and references
  View Computational GO annotations for ZAP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 139 genes
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
87 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • PCA: 1
  • Protein-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 4
  • Negative Genetic: 34
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 28
  • Positive Genetic: 8
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 880
Molecular Weight (Da) 98,865
Isoelectric Point (pI) 7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:333073 to 330431 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2643 333073..330431 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003592
References cited on this page View Complete Literature Guide for ZAP1
1) Zhao H and Eide DJ  (1997) Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol Cell Biol 17(9):5044-52
2) Yuan DS  (2000) Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Genetics 156(1):45-58
3) Zhao H, et al.  (1998) Regulation of zinc homeostasis in yeast by binding of the ZAP1 transcriptional activator to zinc-responsive promoter elements. J Biol Chem 273(44):28713-20
4) Evans-Galea MV, et al.  (2003) Two of the five zinc fingers in the Zap1 transcription factor DNA binding domain dominate site-specific DNA binding. Biochemistry 42(4):1053-61
5) Wu CY, et al.  (2009) Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency. J Biol Chem 284(40):27544-56
6) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104