YTH1/YPR107C Summary Help

Standard Name YTH1 1
Systematic Name YPR107C
Feature Type ORF, Verified
Description Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia (1, 2, 3, 4)
Name Description Yeast THirty kDa Homolog 1
Chromosomal Location
ChrXVI:742064 to 741438 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All YTH1 GO evidence and references
  View Computational GO annotations for YTH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
91 total interaction(s) for 23 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 71
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Biochemical Activity: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 4

Genetic Interactions
  • Positive Genetic: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 208
Molecular Weight (Da) 24,553
Isoelectric Point (pI) 7.99
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:742064 to 741438 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..627 742064..741438 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006311
References cited on this page View Complete Literature Guide for YTH1
1) Barabino SM, et al.  (1997) The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. Genes Dev 11(13):1703-16
2) Barabino SM, et al.  (2000) Distinct roles of two Yth1p domains in 3'-end cleavage and polyadenylation of yeast pre-mRNAs. EMBO J 19(14):3778-87
3) Tacahashi Y, et al.  (2003) Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor. Nucleic Acids Res 31(6):1744-52
4) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30