YTA7/YGR270W Summary Help

Standard Name YTA7 1
Systematic Name YGR270W
Feature Type ORF, Verified
Description Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; relocalizes to the cytosol in response to hypoxia; potentially phosphorylated by Cdc28p (2, 3, 4, 5, 6)
Name Description Yeast Tat-binding Analog 1
Chromosomal Location
ChrVII:1027370 to 1031509 | ORF Map | GBrowse
Gene Ontology Annotations All YTA7 GO evidence and references
  View Computational GO annotations for YTA7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 105 genes
Classical genetics
Large-scale survey
485 total interaction(s) for 297 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 117
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Co-localization: 2
  • PCA: 1
  • Protein-peptide: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 12

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 269
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 6
  • Positive Genetic: 24
  • Synthetic Growth Defect: 32
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 1,379
Molecular Weight (Da) 157,405
Isoelectric Point (pI) 4.91
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:1027370 to 1031509 | ORF Map | GBrowse
This feature contains embedded feature(s): YGR270C-A
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..4140 1027370..1031509 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003502
References cited on this page View Complete Literature Guide for YTA7
1) Schnall R, et al.  (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10(9):1141-55
2) Agostoni Carbone ML, et al.  (1998) A 9359 bp fragment from the right arm of Saccharomyces cerevisiae chromosome VII includes the FOL2 and YTA7 genes and three unknown open reading frames. Yeast 14(6):587-91
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Gradolatto A, et al.  (2008) Saccharomyces cerevisiae Yta7 Regulates Histone Gene Expression. Genetics 179(1):291-304
5) Fillingham J, et al.  (2009) Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression. Mol Cell 35(3):340-51
6) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30