RPT2/YDL007W Summary

RPT2 BASIC INFORMATION

Standard Name	RPT2 1
Systematic Name	YDL007W
Alias	YHS4 , YTA5 2
Feature Type	ORF, Verified
Description	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle (3, 4, 5)
Name Description	Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1

GO Annotations	All RPT2 GO evidence and references
	View Computational GO annotations for RPT2
Molecular Function
Manually curated	ATPase activity (IDA, TAS) endopeptidase activity (TAS)
Biological Process
Manually curated	ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	nucleus (IDA) proteasome regulatory particle, base subcomplex (IPI)

Mutant Phenotype	All RPT2 Phenotype details and references
Classical genetics
null	critical cell size at START (G1 cell-size checkpoint): increased
Large-scale survey
null	cell size: increased inviable
repressible	mitochondrial morphology: abnormal

Interactions	RPT2 All interactions details and references
	143 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 77 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Biochemical Activity: 1 Co-fractionation: 1 Co-purification: 3 PCA: 4 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Synthetic Growth Defect: 15 Synthetic Lethality: 1 Synthetic Rescue: 29

Sequence Information

ChrIV:438045 to 439358 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1314	438045..439358	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002165

RPT2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RPT2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPT2]

1)	Finley D, et al. (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2)	Schnall R, et al. (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10(9):1141-55
3)	Glickman MH, et al. (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18(6):3149-62
4)	Glickman MH, et al. (1999) Functional analysis of the proteasome regulatory particle. Mol Biol Rep 26(1-2):21-8
5)	Rubin DM, et al. (1998) Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J 17(17):4909-19

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