Standard Name	YTA12 1
Systematic Name	YMR089C
Alias	RCA1 2
Feature Type	ORF, Verified
Description	Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes (3, 4)
Name Description	Yeast Tat-binding Analog 1

Chromosomal Location	ChrXIII:448086 to 445609 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for YTA12
Molecular Function
Manually curated	ATP binding (IDA) ATPase activity (IDA, IMP, ISS) metallopeptidase activity (IMP) protein binding (IPI)
Biological Process
Manually curated	protein complex assembly (IMP) protein import into mitochondrial intermembrane space (TAS) proteolysis (IMP) signal peptide processing (IMP)
Cellular Component
Manually curated	m-AAA complex (IDA) mitochondrial inner boundary membrane (IDA) mitochondrial inner membrane (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA)

Classical genetics
null	phosphatidylethanolamine accumulation: decreased cardiolipin accumulation: decreased chronological lifespan: decreased Ccp1-GFP accumulation: decreased MrpL32 accumulation: decreased
reduction of function	respiratory growth: absent
Large-scale survey
null	ornithine accumulation: decreased glycogen accumulation: decreased chitin deposition: increased competitive fitness: decreased heat sensitivity: increased resistance to ethanol: decreased resistance to Calcofluor White: normal resistance to 2,4-dichlorophenol: decreased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	160 total interaction(s) for 120 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-Western: 7 Co-crystal Structure: 1 Co-purification: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 95 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 25 Synthetic Growth Defect: 5 Synthetic Lethality: 7 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:448086 to 445609 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2478 448086..445609 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004695