Standard Name	YSH1
Systematic Name	YLR277C
Alias	BRR5 1
Feature Type	ORF, Verified
Description	Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7)
Name Description	Yeast Seventy-three kDa Homolog

Chromosomal Location	ChrXII:699495 to 697156 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for YSH1
Molecular Function
Manually curated	endoribonuclease activity (IMP, ISS) contributes_to RNA binding (IC)
Biological Process
Manually curated	mRNA cleavage (IMP) mRNA polyadenylation (IMP) RNA splicing (IMP) snoRNA 3'-end processing (IMP) snoRNA splicing (IMP) termination of RNA polymerase II transcription (IMP)
Cellular Component
Manually curated	mRNA cleavage and polyadenylation specificity factor complex (IDA, IPI) mRNA cleavage factor complex (IPI)

Classical genetics
conditional	mRNAs accumulation: decreased mRNAs accumulation: increased poly(A) RNA modification: abnormal cold sensitivity: increased heat sensitivity: increased resistance to cordycepin: decreased vegetative growth: decreased
null	inviable
overexpression	cellular morphology: abnormal
Large-scale survey
conditional	heat sensitivity: increased
null	haploinsufficient inviable
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: decreased resistance to benomyl: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	127 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 101 Affinity Capture-Western: 10 Biochemical Activity: 2 Co-purification: 1 Reconstituted Complex: 8 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:699495 to 697156 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2340 699495..697156 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004267